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Healthy lifestyle a...
Healthy lifestyle and risk of breast cancer among postmenopausal women in the European Prospective Investigation into Cancer and Nutrition cohort study
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McKenzie, Fiona (author)
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Ferrari, Pietro (author)
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Freisling, Heinz (author)
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Chajes, Veronique (author)
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Rinaldi, Sabina (author)
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de Batlle, Jordi (author)
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Dahm, Christina C. (author)
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Overvad, Kim (author)
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Baglietto, Laura (author)
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Dartois, Laureen (author)
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Dossus, Laure (author)
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Lagiou, Pagona (author)
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Trichopoulos, Dimitrios (author)
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Trichopoulou, Antonia (author)
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Krogh, Vittorio (author)
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Panico, Salvatore (author)
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Tumino, Rosario (author)
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Rosso, Stefano (author)
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Bueno-de-Mesquita, H. B(As) (author)
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May, Anne (author)
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Peeters, Petra H. (author)
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- Weiderpass, Elisabete (author)
- Karolinska Institutet
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Buckland, Genevieve (author)
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Sanchez, Maria-Jose (author)
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Navarro, Carmen (author)
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Ardanaz, Eva (author)
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- Andersson, Anne (author)
- Umeå universitet,Onkologi
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- Sund, Malin (author)
- Umeå universitet,Kirurgi
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- Ericson, Ulrika (author)
- Lund University,Lunds universitet,Nutritionsepidemiologi,Forskargrupper vid Lunds universitet,Nutrition Epidemiology,Lund University Research Groups
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- Wirfält, Elisabet (author)
- Lund University,Lunds universitet,Nutritionsepidemiologi,Forskargrupper vid Lunds universitet,Nutrition Epidemiology,Lund University Research Groups
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Key, Tim J. (author)
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Travis, Ruth C. (author)
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Gunter, Marc (author)
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Riboli, Elio (author)
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Vergnaud, Anne-Claire (author)
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Romieu, Isabelle (author)
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(creator_code:org_t)
- 2014-11-16
- 2015
- English.
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In: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 136:11, s. 2640-2648
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http://dx.doi.org/10...
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Abstract
Subject headings
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- Breast cancer is the most common cancer among women and prevention strategies are needed to reduce incidence worldwide. A healthy lifestyle index score (HLIS) was generated to investigate the joint effect of modifiable lifestyle factors on postmenopausal breast cancer risk. The study included 242,918 postmenopausal women from the multinational European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, with detailed information on diet and lifestyle assessed at baseline. The HLIS was constructed from five factors (diet, physical activity, smoking, alcohol consumption and anthropometry) by assigning scores of 0-4 to categories of each component, for which higher values indicate healthier behaviours. Hazard ratios (HR) were estimated by Cox proportional regression models. During 10.9 years of median follow-up, 7,756 incident breast cancer cases were identified. There was a 3% lower risk of breast cancer per point increase of the HLIS. Breast cancer risk was inversely associated with a high HLIS when fourth versus second (reference) categories were compared [adjusted HR=0.74; 95% confidence interval (CI): 0.66-0.83]. The fourth versus the second category of the HLIS was associated with a lower risk for hormone receptor double positive (adjusted HR=0.81, 95% CI: 0.67-0.98) and hormone receptor double negative breast cancer (adjusted HR=0.60, 95% CI: 0.40-0.90). Findings suggest having a high score on an index of combined healthy behaviours reduces the risk of developing breast cancer among postmenopausal women. Programmes which engage women in long term health behaviours should be supported. What's new? How much does behavior really affect cancer risk? These authors set out to measure just that. First, they created a Healthy Lifestyle Index, which quantified five modifiable behaviors, such as smoking and physical activity. Then, using data from the European Prospective Investigation into Cancer and Nutrition (EPIC), they assigned each participant a score between 0 and 4 on each of the behaviors. It turned out that with each point added to a person's Healthy Lifestyle Index score, breast cancer risk fell by 3%, suggesting that public programs to help women maintain these behaviors could be worthwhile for cancer prevention.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- breast cancer
- healthy index
- lifestyle
- prospective studies
- Europe
- breast cancer
- healthy index
- lifestyle
- prospective studies
- Europe
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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McKenzie, Fiona
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Ferrari, Pietro
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Freisling, Heinz
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Chajes, Veroniqu ...
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Rinaldi, Sabina
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de Batlle, Jordi
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show more...
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Dahm, Christina ...
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Overvad, Kim
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Baglietto, Laura
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Dartois, Laureen
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Dossus, Laure
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Lagiou, Pagona
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Trichopoulos, Di ...
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Trichopoulou, An ...
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Krogh, Vittorio
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Panico, Salvator ...
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Tumino, Rosario
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Rosso, Stefano
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Bueno-de-Mesquit ...
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May, Anne
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Peeters, Petra H ...
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Weiderpass, Elis ...
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Buckland, Genevi ...
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Sanchez, Maria-J ...
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Navarro, Carmen
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Ardanaz, Eva
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Andersson, Anne
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Sund, Malin
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Ericson, Ulrika
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Wirfält, Elisabe ...
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Key, Tim J.
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Travis, Ruth C.
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Gunter, Marc
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Riboli, Elio
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Vergnaud, Anne-C ...
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Romieu, Isabelle
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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International Jo ...
- By the university
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Umeå University
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Karolinska Institutet
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Lund University